When speaking about people who are completely out of their minds, "raving lunatics" is a phrase that may come to mind. However, there are several other synonyms that can be used to describe such individuals. For instance, "madmen" denotes people who have lost their sanity and cannot think or behave rationally. "Psychos" are individuals who exhibit deranged or violent behavior due to mental illness or other factors. "Freaks" is a term often used to describe people who are considered abnormal or strange. Lastly, "nutjobs" is another colloquial term used to describe individuals who are mentally unstable or crazy. All these words can be used to describe a range of people with varying degrees of irrational behavior.