CGD stands for chronic granulomatous disease, a rare genetic disorder that affects the immune system's ability to fight off infections. Synonyms for CGD include chronic granulomatous syndrome, CGS, and Bridges-Good syndrome. CGD was first described in the medical literature in 1950 but remained poorly understood until the 1990s, when genetic testing became available. Today, treatment for CGD involves managing infections with antibiotics, antifungals, and antivirals and replacing the immune system through bone marrow or stem cell transplants. While rare, CGD can lead to severe health complications and even death. Early diagnosis and management are critical for patients with the condition.