The phrase "trifled with" is often used to describe someone who treats a situation or person with disregard or disrespect. Some synonyms for this phrase might include "defied," "ignored," "mocked," "belittled," "disparaged," "taunted," or "played with." Whether used in a personal context or a professional one, these words depict someone who is careless or insensitive in their dealings with others. Choosing the right synonym will depend on the intended meaning, as well as the tone and context of the statement. Whatever the case, it's important to choose words that accurately convey the intended sentiment while remaining respectful and appropriate.